2.7M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 24.83 per share. | 17 Mar 2025 | 183 | 47,955 (0%) | 0% | 24.8 | 4,543 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 25.10 per share. | 04 Mar 2025 | 5,569 | 138,730 (0%) | 0% | 25.1 | 139,789 | Common Stock |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2025 | 6,667 | 10,000 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2025 | 6,667 | 0 (0%) | 0% | 0 | Common Stock | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 28.54 per share. | 11 Feb 2025 | 363 | 83,945 (0%) | 0% | 28.5 | 10,360 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 546 | 128,665 (0%) | 0% | 29.5 | 16,120 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 2,824 | 415,695 (0%) | 0% | 29.5 | 83,375 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 826 | 1,147,716 (1%) | 0% | 29.5 | 24,386 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 695 | 144,299 (0%) | 0% | 29.5 | 20,519 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 695 | 84,050 (0%) | 0% | 29.5 | 20,519 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 364 | 70,251 (0%) | 0% | 29.5 | 10,747 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 29.53 per share. | 29 Jan 2025 | 278 | 55,312 (0%) | 0% | 29.5 | 8,208 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 825 | 83,664 (0%) | 0% | 29.5 | 24,357 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 29.52 per share. | 29 Jan 2025 | 365 | 84,308 (0%) | 0% | 29.5 | 10,776 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 1,096 | 48,138 (0%) | 0% | 30.4 | 33,346 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 1,396 | 84,673 (0%) | 0% | 30.4 | 42,474 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 3,088 | 129,211 (0%) | 0% | 30.4 | 93,954 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 13,551 | 418,519 (0%) | 0% | 30.4 | 412,296 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 3,948 | 1,148,542 (1%) | 0% | 30.4 | 120,120 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 3,323 | 144,994 (0%) | 0% | 30.4 | 101,104 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 3,323 | 84,745 (0%) | 0% | 30.4 | 101,104 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 1,751 | 70,615 (0%) | 0% | 30.4 | 53,275 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 1,291 | 55,590 (0%) | 0% | 30.4 | 39,279 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 22 Jan 2025 | 3,948 | 84,489 (0%) | 0% | 30.4 | 120,120 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 45,929 | 132,299 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 1,730 | 86,370 (0%) | 0% | 30.0 | 51,828 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 6,007 | 301,408 (0%) | 0% | 30.0 | 179,959 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 130,662 | 432,070 (0%) | 0% | 0 | Common Stock | |
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 15,045 | 1,152,490 (1%) | 0% | 0 | Common Stock | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 750 | 1,137,445 (1%) | 0% | 30.0 | 22,469 | Common Stock |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 42,762 | 148,317 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 2,201 | 105,555 (0%) | 0% | 30.0 | 65,938 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 2,201 | 88,068 (0%) | 0% | 30.0 | 65,938 | Common Stock |
| Karen Lewis | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 28,508 | 72,366 (0%) | 0% | 0 | Common Stock | |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 1,241 | 43,858 (0%) | 0% | 30.0 | 37,178 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 36,426 | 88,437 (0%) | 0% | 0 | Common Stock | |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 2,145 | 52,011 (0%) | 0% | 30.0 | 64,260 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 715 | 36,643 (0%) | 0% | 30.0 | 21,420 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 12,591 | 49,234 (0%) | 0% | 0 | Common Stock | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 1,235 | 57,561 (0%) | 0% | 30.0 | 36,998 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 28,508 | 86,069 (0%) | 0% | 0 | Common Stock | |
| Caroline Baumal | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.96 per share. | 17 Jan 2025 | 1,853 | 53,707 (0%) | 0% | 30.0 | 55,513 | Common Stock |
| Caroline Baumal | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 39,594 | 93,301 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 2,170 | 88,100 (0%) | 0% | 28.7 | 62,284 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 6,247 | 307,415 (0%) | 0% | 28.7 | 179,302 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 2,288 | 1,138,195 (1%) | 0% | 28.7 | 65,670 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 4,965 | 107,756 (0%) | 0% | 28.7 | 142,506 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 2,685 | 90,269 (0%) | 0% | 28.7 | 77,065 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 1,599 | 45,099 (0%) | 0% | 28.7 | 45,895 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 264 | 56,881 (0%) | 0% | 28.7 | 7,577 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 2,632 | 54,156 (0%) | 0% | 28.7 | 75,544 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 783 | 37,358 (0%) | 0% | 28.7 | 22,474 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 13 Jan 2025 | 1,599 | 58,796 (0%) | 0% | 28.7 | 45,895 | Common Stock |
| Caroline Baumal | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 33.81 per share. | 06 Jan 2025 | 2,816 | 55,560 (0%) | 0% | 33.8 | 95,215 | Common Stock |
| Alec Machiels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 11,199 | 11,199 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 6,267 | 377,028 (0%) | 0% | 0 | Common Stock | |
| Gerald L. Chan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 11,199 | 11,199 | - | - | Stock Option (Right to Buy) | |
| Gerald L. Chan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 6,267 | 17,705 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 6,267 | 158,393 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 11,199 | 11,199 | - | - | Stock Option (Right to Buy) | |
| Stephanie Monaghan O'Brien | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 11,199 | 11,199 | - | - | Stock Option (Right to Buy) | |
| Stephanie Monaghan O'Brien | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 6,267 | 17,705 (0%) | 0% | 0 | Common Stock | |
| Paul Fonteyne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 6,267 | 22,705 (0%) | 0% | 0 | Common Stock | |
| Paul Fonteyne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 11,199 | 11,199 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2024 | 10,054 | 84,946 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2024 | 1,042 | 23,958 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 31 Dec 2024 | 10,054 | 90,270 (0%) | 0% | 13.9 | 139,248 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.95 per share. | 31 Dec 2024 | 1,042 | 80,216 (0%) | 0% | 15.0 | 15,578 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 33.10 per share. | 23 Dec 2024 | 63 | 57,145 (0%) | 0% | 33.1 | 2,085 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 34.24 per share. | 11 Dec 2024 | 5,000 | 112,721 (0%) | 0% | 34.2 | 171,175 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2024 | 182,146 | 472,065 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Sep 2024 | 10,569 | 117,721 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Sep 2024 | 10,569 | 70,136 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Sep 2024 | 4,600 | 0 | - | - | Stock Option (Right to Buy) | |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.19 per share. | 23 Sep 2024 | 4,600 | 152,126 (0%) | 0% | 13.2 | 60,674 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 36.21 per share. | 16 Sep 2024 | 192 | 38,141 (0%) | 0% | 36.2 | 6,952 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 36.09 per share. | 16 Sep 2024 | 29,476 | 107,524 (0%) | 0% | 36.1 | 1,063,789 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 36.79 per share. | 16 Sep 2024 | 7,524 | 100,000 (0%) | 0% | 36.8 | 276,808 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 03 Sep 2024 | 550 | 38,333 (0%) | 0% | 39.5 | 21,720 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 12 Aug 2024 | 5,201 | 60,395 (0%) | 0% | 13.9 | 72,034 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 5,201 | 14,799 | - | - | Stock Option (Right to Buy) | |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.19 per share. | 28 Jun 2024 | 900 | 134,418 (0%) | 0% | 13.2 | 11,871 | Common Stock |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2024 | 900 | 4,600 | - | - | Stock Option (Right to Buy) | |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 39.63 per share. | 21 Jun 2024 | 1,695 | 136,998 (0%) | 0% | 39.6 | 67,173 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 39.22 per share. | 21 Jun 2024 | 35,305 | 138,693 (0%) | 0% | 39.2 | 1,384,662 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2024 | 24,500 | 12,780 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.76 per share. | 20 May 2024 | 24,500 | 1,140,483 (1%) | 0% | 3.8 | 92,120 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.85 per share. | 08 May 2024 | 22,472 | 1,116,083 (1%) | 0% | 42.8 | 962,903 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2024 | 78,907 | 108,622 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.03 per share. | 08 May 2024 | 100 | 1,115,983 (1%) | 0% | 44.0 | 4,403 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.15 per share. | 08 May 2024 | 56,335 | 1,138,555 (1%) | 0% | 42.2 | 2,374,543 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.31 per share. | 08 May 2024 | 78,907 | 1,194,890 (1%) | 0% | 4.3 | 340,089 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 18 Apr 2024 | 14,164 | 79,174 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 18 Apr 2024 | 14,164 | 70,396 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.19 per share. | 12 Apr 2024 | 1,500 | 133,518 (0%) | 0% | 13.2 | 19,785 | Common Stock |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2024 | 1,500 | 5,500 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.76 per share. | 08 Apr 2024 | 69,107 | 1,185,090 (1%) | 0% | 3.8 | 259,842 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2024 | 69,107 | 37,280 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.92 per share. | 08 Apr 2024 | 4,728 | 1,115,983 (1%) | 0% | 54.9 | 259,639 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.12 per share. | 08 Apr 2024 | 64,379 | 1,120,711 (1%) | 0% | 54.1 | 3,483,966 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 58.66 per share. | 01 Apr 2024 | 4,000 | 93,338 (0%) | 0% | 58.7 | 234,640 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 4,000 | 257,903 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.03 per share. | 01 Apr 2024 | 4,000 | 97,338 (0%) | 0% | 10.0 | 40,120 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 57.18 per share. | 19 Mar 2024 | 18,681 | 173,998 (0%) | 0% | 57.2 | 1,068,161 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 56.90 per share. | 18 Mar 2024 | 9,913 | 54,693 (0%) | 0% | 56.9 | 564,050 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 56.46 per share. | 15 Mar 2024 | 184 | 38,883 (0%) | 0% | 56.5 | 10,389 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 57.31 per share. | 13 Mar 2024 | 7,768 | 59,739 (0%) | 0% | 57.3 | 445,161 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 58.13 per share. | 13 Mar 2024 | 3,452 | 56,287 (0%) | 0% | 58.1 | 200,677 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.67 per share. | 08 Mar 2024 | 69,107 | 1,185,090 (1%) | 0% | 3.7 | 253,623 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 69,107 | 106,387 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 62.69 per share. | 08 Mar 2024 | 26,257 | 1,116,083 (1%) | 0% | 62.7 | 1,646,041 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 61.88 per share. | 08 Mar 2024 | 42,750 | 1,142,340 (1%) | 0% | 61.9 | 2,645,173 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.35 per share. | 08 Mar 2024 | 100 | 1,115,983 (1%) | 0% | 63.4 | 6,335 | Common Stock |
| David Watson | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 06 Mar 2024 | 3,762 | 107,152 (0%) | 0% | 13.9 | 52,104 | Common Stock |
| David Watson | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 3,762 | 0 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 6,000 | 261,903 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 63.95 per share. | 01 Mar 2024 | 2,000 | 93,338 (0%) | 0% | 64.0 | 127,900 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 62.86 per share. | 01 Mar 2024 | 4,000 | 95,338 (0%) | 0% | 62.9 | 251,440 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.03 per share. | 01 Mar 2024 | 6,000 | 99,338 (0%) | 0% | 10.0 | 60,180 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.26 per share. | 01 Mar 2024 | 62,503 | 430,587 (0%) | 0% | 64.3 | 4,016,274 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.96 per share. | 01 Mar 2024 | 41,704 | 493,090 (0%) | 0% | 63.0 | 2,625,813 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.21 per share. | 01 Mar 2024 | 28,868 | 534,794 (0%) | 0% | 62.2 | 1,795,965 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.31 per share. | 01 Mar 2024 | 200,000 | 563,662 (0%) | 0% | 4.3 | 862,000 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.76 per share. | 01 Mar 2024 | 50,000 | 363,662 (0%) | 0% | 3.8 | 188,000 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 200,000 | 175,538 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 50,000 | 8,840 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.68 per share. | 01 Mar 2024 | 413 | 313,662 (0%) | 0% | 65.7 | 27,126 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.92 per share. | 01 Mar 2024 | 116,512 | 314,075 (0%) | 0% | 64.9 | 7,563,528 | Common Stock |
| DeLong Mark Jeffrey | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 67.77 per share. | 12 Feb 2024 | 597 | 64,606 (0%) | 0% | 67.8 | 40,457 | Common Stock |
| Francois Cedric | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.77 per share. | 12 Feb 2024 | 3,962 | 313,662 (0%) | 0% | 67.8 | 268,492 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 67.77 per share. | 12 Feb 2024 | 781 | 103,390 (0%) | 0% | 67.8 | 52,926 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 67.77 per share. | 12 Feb 2024 | 1,148 | 1,115,983 (1%) | 0% | 67.8 | 77,796 | Common Stock |
| Adam Townsend J. | Chief Commercial Officer | 12 Feb 2024 | 1,148 | 92,453 (0%) | 0% | 67.8 | 77,796 | Common Stock | |
| Sullivan Timothy E. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 67.77 per share. | 12 Feb 2024 | 1,431 | 93,338 (0%) | 0% | 67.8 | 96,974 | Common Stock |
| Francois Cedric | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 2,843 | 317,624 (0%) | 0% | 64.1 | 182,345 | Common Stock |
| Nicholson Nur | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 835 | 67,507 (0%) | 0% | 64.1 | 53,555 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 906 | 104,171 (0%) | 0% | 64.1 | 58,109 | Common Stock |
| Timothy Sullivan E. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 906 | 94,769 (0%) | 0% | 64.1 | 58,109 | Common Stock |
| Townsend J. Adam | Chief Commercial Officer | 29 Jan 2024 | 906 | 93,601 (0%) | 0% | 64.1 | 58,109 | Common Stock | |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.53 per share. | 29 Jan 2024 | 971 | 57,208 (0%) | 0% | 65.5 | 63,630 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 874 | 1,117,131 (1%) | 0% | 64.1 | 56,057 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 65.53 per share. | 29 Jan 2024 | 883 | 46,387 (0%) | 0% | 65.5 | 57,863 | Common Stock |
| DeLong Jeffrey Mark | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 367 | 65,203 (0%) | 0% | 64.1 | 23,539 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 279 | 58,179 (0%) | 0% | 64.1 | 17,895 | Common Stock |
| Lewis Karen | Chief People Officer | Sale of securities on an exchange or to another person at price $ 64.14 per share. | 29 Jan 2024 | 367 | 47,270 (0%) | 0% | 64.1 | 23,539 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 63.69 per share. | 23 Jan 2024 | 4,286 | 47,637 (0%) | 0% | 63.7 | 272,975 | Common Stock |
| Eisele Jeffrey | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 63.69 per share. | 23 Jan 2024 | 7,378 | 58,458 (0%) | 0% | 63.7 | 469,905 | Common Stock |
| George Chopas James | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 1,061 | 39,067 (0%) | 0% | 65.0 | 68,961 | Common Stock |
| DeLong Mark Jeffrey | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 1,384 | 65,570 (0%) | 0% | 65.0 | 89,954 | Common Stock |
| J. Townsend Adam | Chief Commercial Officer | 22 Jan 2024 | 3,413 | 94,507 (0%) | 0% | 65.0 | 221,831 | Common Stock | |
| Eisele Jeffrey | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 1,607 | 65,836 (0%) | 0% | 65.0 | 104,449 | Common Stock |
| Francois Cedric | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 13,431 | 320,467 (0%) | 0% | 65.0 | 872,961 | Common Stock |
| Watson David | General Counsel | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 4,184 | 105,077 (0%) | 0% | 65.0 | 271,943 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 2,593 | 68,342 (0%) | 0% | 65.0 | 168,535 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 3,913 | 1,118,005 (1%) | 0% | 65.0 | 254,329 | Common Stock |
| Lewis Karen | Chief People Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 1,738 | 51,923 (0%) | 0% | 65.0 | 112,963 | Common Stock |
| E. Sullivan Timothy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Jan 2024 | 3,551 | 95,675 (0%) | 0% | 65.0 | 230,801 | Common Stock |
| Eisele Jeffrey | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.58 per share. | 17 Jan 2024 | 5,207 | 67,443 (0%) | 0% | 65.6 | 341,475 | Common Stock |
| Lewis Karen | Chief People Officer | Sale of securities on an exchange or to another person at price $ 65.58 per share. | 17 Jan 2024 | 3,276 | 53,661 (0%) | 0% | 65.6 | 214,840 | Common Stock |
| Sullivan E. Timothy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 34,533 | 34,533 | - | - | Stock Option (Right to Buy) | |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 12,086 | 12,086 | - | - | Stock Option (Right to Buy) | |
| Nicholson Nur | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 19,508 | 72,792 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 23,748 | 101,461 (0%) | 0% | 0 | Common Stock | |
| Deschatelets Pascal | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 1,632 | 1,121,918 (1%) | 0% | 66.8 | 109,032 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 1,632 | 56,937 (0%) | 0% | 66.8 | 109,032 | Common Stock |
| Baumal Caroline | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 25,445 | 58,376 (0%) | 0% | 0 | Common Stock | |
| Caroline Baumal | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 37,000 | 37,000 | - | - | Stock Option (Right to Buy) | |
| James Chopas George | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 864 | 40,128 (0%) | 0% | 66.8 | 57,723 | Common Stock |
| DeLong Mark Jeffrey | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 16,963 | 68,585 (0%) | 0% | 0 | Common Stock | |
| E. Sullivan Timothy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 2,235 | 99,226 (0%) | 0% | 66.8 | 149,317 | Common Stock |
| Chopas James George | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 8,312 | 40,992 (0%) | 0% | 0 | Common Stock | |
| Nicholson Nur | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 28,367 | 28,367 | - | - | Stock Option (Right to Buy) | |
| Lewis Karen | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 16,963 | 58,569 (0%) | 0% | 0 | Common Stock | |
| Townsend J. Adam | Chief Commercial Officer | 16 Jan 2024 | 23,748 | 100,155 (0%) | 0% | 0 | Common Stock | ||
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 6,743 | 1,123,550 (1%) | 0% | 0 | Common Stock | |
| DeLong Mark Jeffrey | Chief Business & Strat Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 1,631 | 66,954 (0%) | 0% | 66.8 | 108,965 | Common Stock |
| Eisele Jeffrey | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 438 | 72,650 (0%) | 0% | 66.8 | 29,262 | Common Stock |
| Karen Lewis | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 24,666 | 24,666 | - | - | Stock Option (Right to Buy) | |
| DeLong Mark Jeffrey | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 24,666 | 24,666 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 28,367 | 28,367 | - | - | Stock Option (Right to Buy) | |
| Adam J. Townsend | Chief Commercial Officer | 16 Jan 2024 | 34,533 | 34,533 | - | - | Stock Option (Right to Buy) | ||
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 9,805 | 9,805 | - | - | Stock Option (Right to Buy) | |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 23,748 | 113,501 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 19,508 | 73,088 (0%) | 0% | 0 | Common Stock | |
| Townsend J. Adam | Chief Commercial Officer | 16 Jan 2024 | 2,235 | 97,920 (0%) | 0% | 66.8 | 149,317 | Common Stock | |
| Watson David | General Counsel | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 4,240 | 109,261 (0%) | 0% | 66.8 | 283,268 | Common Stock |
| Watson David | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 34,533 | 34,533 | - | - | Stock Option (Right to Buy) | |
| Nur Nicholson | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 66.81 per share. | 16 Jan 2024 | 1,857 | 70,935 (0%) | 0% | 66.8 | 124,064 | Common Stock |
| Baumal Caroline | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.05 per share. | 04 Jan 2024 | 2,751 | 32,931 (0%) | 0% | 60.1 | 165,207 | Common Stock |
| Paul Fonteyne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 5,748 | 5,748 | - | - | Stock Option (Right to Buy) | |
| L. Chan Gerald | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 3,341 | 11,438 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 3,341 | 132,018 (0%) | 0% | 0 | Common Stock | |
| O'Brien Stephanie Monaghan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 3,341 | 11,438 (0%) | 0% | 0 | Common Stock | |
| Alec Machiels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 3,341 | 370,761 (0%) | 0% | 0 | Common Stock | |
| Dunlop Sinclair A. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 5,748 | 5,748 | - | - | Stock Option (Right to Buy) | |
| O'Brien Monaghan Stephanie | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 5,748 | 5,748 | - | - | Stock Option (Right to Buy) | |
| Fonteyne Paul | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 3,341 | 16,438 (0%) | 0% | 0 | Common Stock | |
| Machiels Alec | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 5,748 | 5,748 | - | - | Stock Option (Right to Buy) | |
| Gerald L. Chan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2024 | 5,748 | 5,748 | - | - | Stock Option (Right to Buy) | |
| Eisele Jeffrey | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 60.23 per share. | 26 Dec 2023 | 235 | 53,580 (0%) | 0% | 60.2 | 14,154 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 57.87 per share. | 26 Dec 2023 | 68 | 53,815 (0%) | 0% | 57.9 | 3,935 | Common Stock |
| David Watson | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2023 | 7,905 | 3,762 | - | - | Stock Option (Right to Buy) | |
| Watson David | General Counsel | Sale of securities on an exchange or to another person at price $ 57.38 per share. | 19 Dec 2023 | 2,300 | 89,753 (0%) | 0% | 57.4 | 131,980 | Common Stock |
| David Watson | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 19 Dec 2023 | 7,905 | 93,658 (0%) | 0% | 13.8 | 109,484 | Common Stock |
| Watson David | General Counsel | Sale of securities on an exchange or to another person at price $ 57.00 per share. | 19 Dec 2023 | 1,605 | 92,053 (0%) | 0% | 57.0 | 91,492 | Common Stock |
| Dunlop Sinclair A. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 6,274 | 7,000 | - | - | Stock Option (Right to Buy) | |
| A. Dunlop Sinclair | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.19 per share. | 14 Dec 2023 | 6,274 | 128,677 (0%) | 0% | 13.2 | 82,754 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 61.14 per share. | 01 Dec 2023 | 24,000 | 192,679 (0%) | 0% | 61.1 | 1,467,240 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 01 Dec 2023 | 10,000 | 68,299 (0%) | 0% | 60 | 600,000 | Common Stock |
| J. Townsend Adam | Chief Commercial Officer | 01 Dec 2023 | 67,557 | 118,850 (0%) | 0% | 60.5 | 4,087,327 | Common Stock | |
| J. Townsend Adam | Chief Commercial Officer | 01 Dec 2023 | 110,000 | 186,407 (0%) | 0% | 15.1 | 1,659,900 | Common Stock | |
| Scheibler Lukas | Chief Research Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 01 Dec 2023 | 10,000 | 78,299 (0%) | 0% | 13.9 | 138,500 | Common Stock |
| Adam Townsend J. | Chief Commercial Officer | 01 Dec 2023 | 110,000 | 172,500 | - | - | Stock Option (Right to Buy) | ||
| Scheibler Lukas | Chief Research Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2023 | 10,000 | 39,391 | - | - | Stock Option (Right to Buy) | |
| J. Townsend Adam | Chief Commercial Officer | 01 Dec 2023 | 42,443 | 76,407 (0%) | 0% | 61.3 | 2,601,977 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 01 Sep 2023 | 300,000 | 574,655 (0%) | 0% | 2.7 | 801,000 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2023 | 300,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.44 per share. | 01 Sep 2023 | 10,284 | 424,655 (0%) | 0% | 42.4 | 436,453 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.70 per share. | 01 Sep 2023 | 139,716 | 434,939 (0%) | 0% | 41.7 | 5,826,506 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 41.23 per share. | 31 Aug 2023 | 551 | 30,312 (0%) | 0% | 41.2 | 22,716 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Aug 2023 | 18,500 | 1,065,313 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.66 per share. | 08 Aug 2023 | 12,000 | 1,053,313 (1%) | 0% | 23.7 | 283,920 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Aug 2023 | 18,500 | 54,494 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2023 | 49,779 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 21 Jul 2023 | 49,779 | 367,420 (0%) | 0% | 2.7 | 132,910 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2023 | 50,000 | 54,779 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 20 Jul 2023 | 50,000 | 317,641 (0%) | 0% | 2.7 | 133,500 | Common Stock |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 64.79 per share. | 17 Jul 2023 | 1,250 | 267,641 (0%) | 0% | 64.8 | 80,988 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,250 | 104,779 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 Jul 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 84.55 per share. | 10 Jul 2023 | 12,000 | 1,046,813 (1%) | 0% | 84.6 | 1,014,600 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2023 | 18,500 | 72,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 10 Jul 2023 | 18,500 | 1,058,813 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2023 | 6,779 | 282,061 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 91.10 per share. | 03 Jul 2023 | 300 | 77,713 (0%) | 0% | 91.1 | 27,329 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.42 per share. | 03 Jul 2023 | 3,287 | 78,013 (0%) | 0% | 90.4 | 297,199 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.41 per share. | 03 Jul 2023 | 3,192 | 81,300 (0%) | 0% | 89.4 | 285,400 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.03 per share. | 03 Jul 2023 | 6,779 | 84,492 (0%) | 0% | 10.0 | 67,993 | Common Stock |
| David Watson | General Counsel | Sale of securities on an exchange or to another person at price $ 89.98 per share. | 03 Jul 2023 | 8,510 | 85,753 (0%) | 0% | 90.0 | 765,730 | Common Stock |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Jun 2023 | 12,750 | 80,705 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Jun 2023 | 12,750 | 94,263 (0%) | 0% | 0 | Common Stock | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2023 | 1,250 | 106,029 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 88.41 per share. | 20 Jun 2023 | 1,250 | 267,641 (0%) | 0% | 88.4 | 110,513 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 20 Jun 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 91.35 per share. | 08 Jun 2023 | 12,000 | 1,040,313 (1%) | 0% | 91.4 | 1,096,200 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2023 | 18,500 | 91,494 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Jun 2023 | 18,500 | 1,052,313 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.03 per share. | 05 Jun 2023 | 69,779 | 147,492 (0%) | 0% | 10.0 | 699,883 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2023 | 69,779 | 288,840 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.83 per share. | 05 Jun 2023 | 30,506 | 77,713 (0%) | 0% | 89.8 | 2,740,229 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.36 per share. | 05 Jun 2023 | 7,064 | 108,219 (0%) | 0% | 88.4 | 624,210 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.79 per share. | 05 Jun 2023 | 30,609 | 115,283 (0%) | 0% | 87.8 | 2,687,121 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.60 per share. | 05 Jun 2023 | 1,600 | 145,892 (0%) | 0% | 90.6 | 144,967 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 86.00 per share. | 01 Jun 2023 | 5,000 | 41,504 (0%) | 0% | 86 | 430,000 | Common Stock |
| Karen Lewis | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2023 | 5,000 | 106,000 | - | - | Stock Option (Right to Buy) | |
| Karen Lewis | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.11 per share. | 01 Jun 2023 | 5,000 | 46,504 (0%) | 0% | 34.1 | 170,550 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 24 May 2023 | 20,000 | 654,211 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 24 May 2023 | 20,000 | 274,655 (0%) | 0% | 0 | Common Stock | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 May 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 88.66 per share. | 17 May 2023 | 1,250 | 267,641 (0%) | 0% | 88.7 | 110,825 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 1,250 | 107,279 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.17 per share. | 16 May 2023 | 934 | 303,721 (0%) | 0% | 83.2 | 77,682 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2023 | 20,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2023 | 30,000 | 320,000 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 16 May 2023 | 20,000 | 294,655 (0%) | 0% | 2.7 | 53,400 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 87.67 per share. | 16 May 2023 | 2,120 | 274,655 (0%) | 0% | 87.7 | 185,869 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 87.02 per share. | 16 May 2023 | 7,528 | 276,775 (0%) | 0% | 87.0 | 655,059 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.90 per share. | 16 May 2023 | 3,007 | 284,303 (0%) | 0% | 85.9 | 258,305 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 16 May 2023 | 14,611 | 287,310 (0%) | 0% | 85.0 | 1,242,065 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 83.84 per share. | 16 May 2023 | 1,800 | 301,921 (0%) | 0% | 83.8 | 150,921 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 16 May 2023 | 30,000 | 304,655 (0%) | 0% | 2.7 | 80,100 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 May 2023 | 18,500 | 1,045,813 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2023 | 18,500 | 109,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 92.39 per share. | 08 May 2023 | 12,000 | 1,033,813 (1%) | 0% | 92.4 | 1,108,680 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 May 2023 | 20,000 | 77,713 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 May 2023 | 20,000 | 56,232 (0%) | 0% | 0 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 May 2023 | 5,000 | 75,995 (0%) | 0% | 82.7 | 413,550 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 May 2023 | 5,000 | 80,995 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 May 2023 | 5,000 | 282,500 | - | - | Stock Option (Right to Buy) | ||
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 21 Apr 2023 | 67,955 | 67,955 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 21 Apr 2023 | 67,955 | 107,013 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Apr 2023 | 36,232 | 36,232 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Apr 2023 | 36,232 | 97,713 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 30,000 | 370,000 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 18 Apr 2023 | 20,000 | 657,601 (0%) | 0% | 2.7 | 53,400 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 82.02 per share. | 18 Apr 2023 | 30,000 | 637,601 (0%) | 0% | 82.0 | 2,460,720 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 18 Apr 2023 | 30,000 | 667,601 (0%) | 0% | 2.7 | 80,100 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 20,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 1,250 | 108,529 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 81.05 per share. | 17 Apr 2023 | 1,250 | 267,641 (0%) | 0% | 81.1 | 101,313 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 Apr 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 78.21 per share. | 10 Apr 2023 | 12,000 | 1,027,313 (1%) | 0% | 78.2 | 938,520 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2023 | 18,500 | 128,494 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 10 Apr 2023 | 18,500 | 1,039,313 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 26,990 | 634,211 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 380,000 | 607,221 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 227,221 | 227,221 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 26,990 | 637,601 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 380,000 | 664,591 (0%) | 0% | 0 | Common Stock | |
| Cedric Francois | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Apr 2023 | 227,221 | 1,044,591 (1%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 74.05 per share. | 03 Apr 2023 | 500 | 131,297 (0%) | 0% | 74.1 | 37,025 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Apr 2023 | 5,000 | 287,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 03 Apr 2023 | 5,000 | 75,995 (0%) | 0% | 74.1 | 370,250 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Apr 2023 | 5,000 | 80,995 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 03 Apr 2023 | 5,000 | 41,430 (0%) | 0% | 75 | 375,000 | Common Stock |
| Karen Lewis | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 5,000 | 111,000 | - | - | Stock Option (Right to Buy) | |
| Karen Lewis | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.11 per share. | 03 Apr 2023 | 5,000 | 46,430 (0%) | 0% | 34.1 | 170,550 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 21 Mar 2023 | 20,000 | 1,164,591 (1%) | 0% | 2.7 | 53,400 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 21 Mar 2023 | 30,000 | 1,174,591 (1%) | 0% | 2.7 | 80,100 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.74 per share. | 21 Mar 2023 | 30,000 | 1,144,591 (1%) | 0% | 62.7 | 1,882,332 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2023 | 7,221 | 273,779 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2023 | 100,000 | 58,840 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2023 | 20,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2023 | 30,000 | 420,000 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.85 per share. | 21 Mar 2023 | 7,221 | 1,271,812 (1%) | 0% | 13.9 | 100,011 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.76 per share. | 21 Mar 2023 | 100,000 | 1,264,591 (1%) | 0% | 3.8 | 376,000 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 Mar 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2023 | 1,250 | 109,779 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 64.03 per share. | 17 Mar 2023 | 1,250 | 267,641 (0%) | 0% | 64.0 | 80,038 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2023 | 18,500 | 146,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Mar 2023 | 18,500 | 1,032,813 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.79 per share. | 08 Mar 2023 | 12,000 | 1,020,813 (1%) | 0% | 63.8 | 765,480 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Mar 2023 | 5,000 | 75,995 (0%) | 0% | 63.8 | 319,200 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Mar 2023 | 5,000 | 80,995 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Mar 2023 | 5,000 | 292,500 | - | - | Stock Option (Right to Buy) | ||
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 65.33 per share. | 01 Mar 2023 | 500 | 131,797 (0%) | 0% | 65.3 | 32,665 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2023 | 100,000 | 158,840 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.76 per share. | 27 Feb 2023 | 100,000 | 1,144,591 (1%) | 0% | 3.8 | 376,000 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 68.76 per share. | 23 Feb 2023 | 1,104 | 41,430 (0%) | 0% | 68.8 | 75,911 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 68.76 per share. | 23 Feb 2023 | 1,646 | 53,883 (0%) | 0% | 68.8 | 113,179 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 974 | 133,945 (0%) | 0% | 58.5 | 56,979 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 11,683 | 134,919 (0%) | 0% | 0 | Common Stock | |
| Timothy E. Sullivan | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 16,572 | 16,572 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 13,908 | 1,046,193 (1%) | 0% | 0 | Common Stock | |
| Cedric Francois | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 19,728 | 19,728 | - | - | Stock Option (Right to Buy) | |
| Cedric Francois | Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 1,602 | 1,044,591 (1%) | 0% | 58.5 | 93,717 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,886 | 1,015,508 (1%) | 0% | 0 | Common Stock | |
| Pascal Deschatelets | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 1,195 | 1,014,313 (1%) | 0% | 58.5 | 69,908 | Common Stock |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,886 | 175,793 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | |
| David Watson | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 825 | 174,968 (0%) | 0% | 58.5 | 48,263 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 715 | 69,643 (0%) | 0% | 58.5 | 41,828 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,886 | 70,358 (0%) | 0% | 0 | Common Stock | |
| Lukas Scheibler | Chief Research Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | |
| Adam J. Townsend | Chief Commercial Officer | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 21 Feb 2023 | 1,041 | 75,995 (0%) | 0% | 58.5 | 60,899 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 21 Feb 2023 | 9,886 | 77,036 (0%) | 0% | 0 | Common Stock | ||
| Karen Lewis | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 6,628 | 43,087 (0%) | 0% | 0 | Common Stock | |
| Karen Lewis | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,402 | 9,402 | - | - | Stock Option (Right to Buy) | |
| Karen Lewis | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 553 | 42,534 (0%) | 0% | 58.5 | 32,351 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 825 | 55,529 (0%) | 0% | 58.5 | 48,263 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,886 | 56,354 (0%) | 0% | 0 | Common Stock | |
| Nur Nicholson | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 9,886 | 64,328 (0%) | 0% | 0 | Common Stock | |
| Nur Nicholson | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 825 | 63,503 (0%) | 0% | 58.5 | 48,263 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 14,023 | 14,023 | - | - | Stock Option (Right to Buy) | |
| James George Chopas | VP/Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 334 | 30,863 (0%) | 0% | 58.5 | 19,539 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 4,044 | 31,197 (0%) | 0% | 0 | Common Stock | |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 5,737 | 5,737 | - | - | Stock Option (Right to Buy) | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 5,280 | 51,782 (0%) | 0% | 0 | Common Stock | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2023 | 7,489 | 7,489 | - | - | Stock Option (Right to Buy) | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.50 per share. | 21 Feb 2023 | 441 | 51,341 (0%) | 0% | 58.5 | 25,799 | Common Stock |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 52.38 per share. | 17 Feb 2023 | 1,250 | 267,641 (0%) | 0% | 52.4 | 65,475 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 Feb 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2023 | 1,250 | 111,029 | - | - | Stock Option (Right to Buy) | |
| Timothy E. Sullivan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 975 | 123,236 (0%) | 0% | 51.2 | 49,930 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 3,958 | 1,032,285 (1%) | 0% | 51.2 | 202,689 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 1,134 | 1,005,622 (1%) | 0% | 51.2 | 58,072 | Common Stock |
| David Watson | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 532 | 165,907 (0%) | 0% | 51.2 | 27,244 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 678 | 60,472 (0%) | 0% | 51.2 | 34,720 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 10 Feb 2023 | 782 | 67,150 (0%) | 0% | 51.2 | 40,046 | Common Stock | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 51.21 per share. | 10 Feb 2023 | 670 | 46,502 (0%) | 0% | 51.2 | 34,311 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.45 per share. | 08 Feb 2023 | 12,000 | 1,006,756 (1%) | 0% | 54.5 | 653,400 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2023 | 18,500 | 165,494 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Feb 2023 | 18,500 | 1,018,756 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Feb 2023 | 5,000 | 67,932 (0%) | 0% | 55.9 | 279,250 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Feb 2023 | 5,000 | 297,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 03 Feb 2023 | 5,000 | 72,932 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 52.61 per share. | 01 Feb 2023 | 500 | 132,297 (0%) | 0% | 52.6 | 26,305 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 52.76 per share. | 30 Jan 2023 | 883 | 36,459 (0%) | 0% | 52.8 | 46,587 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 52.76 per share. | 30 Jan 2023 | 883 | 46,468 (0%) | 0% | 52.8 | 46,587 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 551 | 124,211 (0%) | 0% | 52.8 | 29,076 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 2,879 | 1,036,243 (1%) | 0% | 52.8 | 151,925 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 832 | 1,000,256 (1%) | 0% | 52.8 | 43,905 | Common Stock |
| David Watson | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 551 | 166,439 (0%) | 0% | 52.8 | 29,076 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 542 | 61,150 (0%) | 0% | 52.8 | 28,601 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 27 Jan 2023 | 551 | 67,932 (0%) | 0% | 52.8 | 29,076 | Common Stock | |
| Karen Lewis | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 367 | 37,342 (0%) | 0% | 52.8 | 19,367 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 367 | 47,351 (0%) | 0% | 52.8 | 19,367 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 551 | 54,442 (0%) | 0% | 52.8 | 29,076 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.77 per share. | 27 Jan 2023 | 367 | 47,172 (0%) | 0% | 52.8 | 19,367 | Common Stock |
| Karen Lewis | Chief People Officer | Sale of securities on an exchange or to another person at price $ 51.58 per share. | 23 Jan 2023 | 2,955 | 37,709 (0%) | 0% | 51.6 | 152,419 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 51.58 per share. | 23 Jan 2023 | 4,479 | 47,718 (0%) | 0% | 51.6 | 231,027 | Common Stock |
| Timothy E. Sullivan | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,379 | 124,762 (0%) | 0% | 52.1 | 123,827 | Common Stock |
| Cedric Francois | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 9,453 | 1,039,122 (1%) | 0% | 52.1 | 492,029 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,326 | 1,001,088 (1%) | 0% | 52.0 | 121,068 | Common Stock |
| David Watson | General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,034 | 166,990 (0%) | 0% | 52.1 | 105,870 | Common Stock |
| Lukas Scheibler | Chief Research Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,015 | 61,692 (0%) | 0% | 52.1 | 104,881 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 20 Jan 2023 | 1,912 | 68,483 (0%) | 0% | 52.1 | 99,520 | Common Stock | |
| Victoria L. Brown | Program Team Lead | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 1,412 | 23,556 (0%) | 0% | 52.1 | 73,495 | Common Stock |
| Karen Lewis | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 1,411 | 40,664 (0%) | 0% | 52.1 | 73,443 | Common Stock |
| Jeffrey Eisele | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,033 | 52,197 (0%) | 0% | 52.1 | 105,818 | Common Stock |
| Nur Nicholson | Chief Technical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 2,034 | 54,993 (0%) | 0% | 52.1 | 105,870 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 919 | 27,153 (0%) | 0% | 52.1 | 47,834 | Common Stock |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.05 per share. | 20 Jan 2023 | 1,149 | 47,539 (0%) | 0% | 52.0 | 59,805 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 1,250 | 112,279 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 52.42 per share. | 17 Jan 2023 | 1,250 | 267,641 (0%) | 0% | 52.4 | 65,525 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 17 Jan 2023 | 1,250 | 268,891 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 19,634 | 1,003,414 (1%) | 0% | 0 | Common Stock | |
| Pascal Deschatelets | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 30,845 | 30,845 | - | - | Stock Option (Right to Buy) | |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 29,452 | 169,024 (0%) | 0% | 0 | Common Stock | |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 37,708 | 37,708 | - | - | Stock Option (Right to Buy) | |
| David Watson | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 24,003 | 139,572 (0%) | 0% | 0 | Common Stock | |
| Lukas Scheibler | Chief Research Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 35,472 | 35,472 | - | - | Stock Option (Right to Buy) | |
| Lukas Scheibler | Chief Research Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 22,580 | 63,707 (0%) | 0% | 0 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 12 Jan 2023 | 27,488 | 70,395 (0%) | 0% | 0 | Common Stock | ||
| Adam J. Townsend | Chief Commercial Officer | 12 Jan 2023 | 43,183 | 43,183 | - | - | Stock Option (Right to Buy) | ||
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 35,472 | 35,472 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Eisele | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 22,580 | 54,230 (0%) | 0% | 0 | Common Stock | |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 9,621 | 28,072 (0%) | 0% | 0 | Common Stock | |
| James George Chopas | VP/Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 15,114 | 15,114 | - | - | Stock Option (Right to Buy) | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 30,845 | 30,845 | - | - | Stock Option (Right to Buy) | |
| Mark Jeffrey DeLong | Chief Business & Strat Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2023 | 19,634 | 48,688 (0%) | 0% | 0 | Common Stock | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 46.08 per share. | 09 Jan 2023 | 12,000 | 983,780 (1%) | 0% | 46.1 | 552,960 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2023 | 18,500 | 183,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 09 Jan 2023 | 18,500 | 995,780 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Federico Grossi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.79 per share. | 05 Jan 2023 | 2,500 | 94,884 (0%) | 0% | 48.8 | 121,975 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 50.70 per share. | 03 Jan 2023 | 500 | 132,797 (0%) | 0% | 50.7 | 25,350 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Jan 2023 | 5,000 | 302,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 03 Jan 2023 | 5,000 | 42,907 (0%) | 0% | 50.7 | 253,500 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Jan 2023 | 5,000 | 47,907 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Caroline Baumal | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 49,000 | 49,000 | - | - | Stock Option (Right to Buy) | |
| Caroline Baumal | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 35,549 | 35,682 (0%) | 0% | 0 | Common Stock | |
| Alec Machiels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 7,441 | 7,441 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 3,867 | 267,641 (0%) | 0% | 0 | Common Stock | |
| Gerald L. Chan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 3,867 | 8,097 (0%) | 0% | 0 | Common Stock | |
| Gerald L. Chan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 7,441 | 7,441 | - | - | Stock Option (Right to Buy) | |
| A. Sinclair Dunlop | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 3,867 | 133,297 (0%) | 0% | 0 | Common Stock | |
| A. Sinclair Dunlop | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 7,441 | 7,441 | - | - | Stock Option (Right to Buy) | |
| Stephanie Monaghan O'Brien | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 7,441 | 7,441 | - | - | Stock Option (Right to Buy) | |
| Stephanie Monaghan O'Brien | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 3,867 | 8,097 (0%) | 0% | 0 | Common Stock | |
| Paul Fonteyne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 3,867 | 13,097 (0%) | 0% | 0 | Common Stock | |
| Paul Fonteyne | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2023 | 7,441 | 7,441 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.67 per share. | 29 Dec 2022 | 7,000 | 977,280 (1%) | 0% | 3.7 | 25,690 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 220,494 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 52.35 per share. | 15 Dec 2022 | 1,250 | 263,774 (0%) | 0% | 52.4 | 65,438 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2022 | 1,250 | 113,529 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 15 Dec 2022 | 1,250 | 265,024 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Dec 2022 | 18,500 | 982,280 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2022 | 18,500 | 202,494 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 47.50 per share. | 08 Dec 2022 | 12,000 | 970,280 (1%) | 0% | 47.5 | 570,000 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 05 Dec 2022 | 5,000 | 47,907 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 05 Dec 2022 | 5,000 | 307,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 05 Dec 2022 | 5,000 | 42,907 (0%) | 0% | 50.4 | 251,900 | Common Stock | |
| Federico Grossi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.93 per share. | 01 Dec 2022 | 2,500 | 97,384 (0%) | 0% | 49.9 | 124,825 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 49.93 per share. | 01 Dec 2022 | 500 | 129,430 (0%) | 0% | 49.9 | 24,965 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 15 Nov 2022 | 1,250 | 265,024 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2022 | 1,250 | 114,779 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 48.01 per share. | 15 Nov 2022 | 1,250 | 263,774 (0%) | 0% | 48.0 | 60,013 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 46.47 per share. | 08 Nov 2022 | 12,000 | 963,780 (1%) | 0% | 46.5 | 557,640 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Nov 2022 | 18,500 | 220,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Nov 2022 | 18,500 | 975,780 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Nov 2022 | 5,000 | 47,907 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Nov 2022 | 5,000 | 312,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 03 Nov 2022 | 5,000 | 42,907 (0%) | 0% | 58.5 | 292,700 | Common Stock | |
| Federico Grossi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.83 per share. | 01 Nov 2022 | 2,500 | 99,884 (0%) | 0% | 60.8 | 152,075 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 60.83 per share. | 01 Nov 2022 | 500 | 129,930 (0%) | 0% | 60.8 | 30,415 | Common Stock |
| Victoria L. Brown | Program Team Lead | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.41 per share. | 26 Oct 2022 | 130 | 24,844 (0%) | 0% | 58.4 | 7,593 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.00 per share. | 20 Oct 2022 | 130 | 18,451 (0%) | 0% | 58 | 7,540 | Common Stock |
| Mark Jeffrey DeLong | Senior Vice President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.00 per share. | 20 Oct 2022 | 196 | 29,054 (0%) | 0% | 58 | 11,368 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 14 Oct 2022 | 1,250 | 265,024 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 59.31 per share. | 14 Oct 2022 | 1,250 | 263,774 (0%) | 0% | 59.3 | 74,138 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 1,250 | 116,029 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 57.50 per share. | 10 Oct 2022 | 12,000 | 957,280 (1%) | 0% | 57.5 | 690,000 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Oct 2022 | 18,500 | 239,494 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 10 Oct 2022 | 18,500 | 969,280 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| Federico Grossi | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 66.69 per share. | 03 Oct 2022 | 2,500 | 102,384 (0%) | 0% | 66.7 | 166,725 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 03 Oct 2022 | 5,000 | 317,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 03 Oct 2022 | 5,000 | 42,907 (0%) | 0% | 66.7 | 333,450 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 03 Oct 2022 | 5,000 | 47,907 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Alec Machiels | Director | Sale of securities on an exchange or to another person at price $ 66.00 per share. | 15 Sep 2022 | 1,250 | 263,774 (0%) | 0% | 66 | 82,500 | Common Stock |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2022 | 1,250 | 117,279 | - | - | Stock Option (Right to Buy) | |
| Alec Machiels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 15 Sep 2022 | 1,250 | 265,024 (0%) | 0% | 2.7 | 3,338 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.98 per share. | 08 Sep 2022 | 12,000 | 950,780 (1%) | 0% | 64.0 | 767,760 | Common Stock |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 18,500 | 257,994 | - | - | Stock Option (Right to Buy) | |
| Pascal Deschatelets | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.67 per share. | 08 Sep 2022 | 18,500 | 962,780 (1%) | 0% | 2.7 | 49,395 | Common Stock |
| A. Sinclair Dunlop | Director | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 08 Sep 2022 | 15,000 | 240,679 (0%) | 0% | 65 | 975,000 | Common Stock |
| Adam J. Townsend | Chief Commercial Officer | 06 Sep 2022 | 5,000 | 42,907 (0%) | 0% | 60.4 | 301,900 | Common Stock | |
| Adam J. Townsend | Chief Commercial Officer | 06 Sep 2022 | 5,000 | 322,500 | - | - | Stock Option (Right to Buy) | ||
| Adam J. Townsend | Chief Commercial Officer | 06 Sep 2022 | 5,000 | 47,907 (0%) | 0% | 15.1 | 75,450 | Common Stock | |
| Federico Grossi | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 60.30 per share. | 01 Sep 2022 | 2,500 | 104,884 (0%) | 0% | 60.3 | 150,750 | Common Stock |
| James George Chopas | VP/Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.84 per share. | 30 Aug 2022 | 558 | 18,581 (0%) | 0% | 58.8 | 32,833 | Common Stock |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2022 | 4,306 | 13,274 | - | - | Stock Option (Right to Buy) | |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.19 per share. | 25 Aug 2022 | 4,306 | 130,430 (0%) | 0% | 13.2 | 56,796 | Common Stock |
| Mark Jeffrey DeLong | Senior Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.52 per share. | 17 Aug 2022 | 5,000 | 34,250 (0%) | 0% | 15.5 | 77,600 | Common Stock |
| Mark Jeffrey DeLong | Senior Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2022 | 5,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Mark Jeffrey DeLong | Senior Vice President | Sale of securities on an exchange or to another person at price $ 69.50 per share. | 17 Aug 2022 | 5,000 | 29,250 (0%) | 0% | 69.5 | 347,500 | Common Stock |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.00 per share. | 16 Aug 2022 | 25,394 | 126,124 (0%) | 0% | 14 | 355,516 | Common Stock |
| A. Sinclair Dunlop | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2022 | 25,394 | 0 | - | - | Stock Option (Right to Buy) |